Passage Bio

Passage Bio is a genetic medicines company based in Philadelphia, PA that is developing a deep pipeline of adeno-associated virus (AAV) delivered therapeutics for the treatment of rare monogenic central nervous system disorders (CNS). We seek to deliver transformative therapies to patients by leveraging our team’s decades of experience, including our founders, as well as the transformative potential genetic medicine technology to develop treatments that improve outcomes for patients with serious, life-threatening, rare CNS disorders. Critical to this strategy is what we believe to be a differentiated approach to genetic medicine development via our collaboration with Penn’s GTP and Orphan Disease Center, led by our co-founder and Chief Scientific Advisor Dr. James Wilson. In addition to our strategy, we have recruited, beginning with our founders, Dr. Squinto, Dr. Wilson and Dr. Yamada, a world class team of leaders who have decades of experience in working in, creating and successfully growing rare disease, central nervous disorders and gene therapy focused companies. We have assembled a deep pipeline of genetic medicine product candidates, including our three lead product candidates: PBGM01 for the treatment of GM1 gangliosidosis (GM1), PBFT02 for the treatment of frontotemporal dementia (FTD) and PBKR03 for the treatment of Krabbe disease.