Innovative Cancer Therapeutics Our initial product, NB-103, is being developed for the treatment of advanced colorectal cancer. NB-103 is FdUMP (fluorodeoxyuridine monophosphate), a highly potent chemotherapeutic agent, encapsulated by a pegylated calcium phosphosilicate nanoparticle (NanoJacket) that will deliver enhanced efficacy and lower rates of dose-limiting toxicity than currently approved fluoropyrimidines by: ? Avoiding cellular metabolism, in particular in the liver that inactivates >80% of a dose of 5-FU, ? Achieving intracellular levels of FdUMP in cancer cells that are not possible with either 5-FU or capecitabine. ? Decreasing the number of patients who discontinue fluoropyrimidine therapy due to toxicities.
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