Hope for Depression Research Foundation

HDRF meets a critical need for innovation in depression research. Hundreds of millions worldwide suffer from depression each year. In the U.S. alone, over 18 million people have Major Depressive Disorder, and it is the leading cause of disability in ages 15-44. Yet, since the introduction of the SSRI antidepressants over 28 years ago, there has been virtually no change in the basic treatment of depression or major new category of medication. Sadly, over 50% of those diagnosed do not respond to existing medications.

In 2010,HDRF launched its Depression Task Force (DTF) – an outstanding collaboration of world-renowned scientists from different research institutions across the U.S. and Canada. These scientists have developed an unprecedented research plan to find the brain circuits of depression and targets for new treatments. Their plan integrates the most advanced knowledge in genetics, epigenetics, molecular biology, electrophysiology, and brain imaging. To accelerate breakthrough research, the DTF shares ongoing results, in real time, at the new HDRF Data Center.

HDRF was founded in 2006 by Audrey Gruss in memory of her mother Hope, who struggle with depression for decades. It is headquartered in New York City, with offices in West Palm Beach. 100% of all donations go directly to research.