Clover Biopharmaceuticals

We are a global clinical-stage biotechnology company committed to developing novel vaccines and biologic therapeutic candidates to address the world’s most life-threatening diseases and public health threats. The Trimer-Tag© technology platform is a product development platform for the creation of novel vaccines and biologic therapies. We have leveraged the Trimer-Tag© technology platform to become a COVID-19 vaccine developer and potentially one of the first companies to commercialize a protein-based COVID-19 vaccine globally through the COVAX Facility.

The Trimer-Tag©. technology platform can trimerize any protein of interest and target a broad spectrum of naturally trimerization-dependent disease and biologic targets. These include dozens of enveloped RNA viruses (e.g. coronaviruses, rabies, respiratory syncytial virus (RSV), influenza, human immunodeficiency virus (HIV), and Ebola) and the tumor necrosis factor (TNF) superfamily (TNFSF), which have diverse biological functions and are linked to serious diseases, such as certain cancers and autoimmune disorders.

Our product pipeline consisted of (i) six Trimer-Tag© subunit vaccine candidates, including SCB-2019 (CpG 1018/Alum), for which we are conducting SPECTRA (Study Evaluating Protective-Efficacy and Safety of Clover’s Trimeric Recombinant Protein-based and Adjuvanted COVID-19 Vaccine), a global pivotal Phase 2/3 clinical trial, (ii) two Trimer-Tag© oncology product candidates, including SCB-313 for which we are conducting five Phase 1 clinical trials in China and Australia, and (iii) three Fc-fusion product candidates, including SCB-808, for which we are conducting a pivotal Phase 3 clinical trial in China.