Bicycle Therapeutics
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Bicycle Therapeutics

https://www.bicycletherapeutics.com/
Last activity: 24.10.2024
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Categories: BioTechBuildingDrugHumanITManagementMedtechPlatformPublicResearch
We are Bicycle Therapeutics, a clinical-stage biopharmaceutical company. We didn’t wait for the next advance against cancer. We created it.

Based on groundbreaking work conceived in the laboratory of Sir Greg Winter with the help of Professor Christian Heinis, we are pioneering the development of bicyclic peptides, or Bicycles® – a novel class of versatile, chemically synthesized medicines. Bicycles are fully synthetic short peptides constrained to form two loops which stabilize their structural geometry. This constraint is designed to confer high affinity and selectivity, and the relatively large surface area presented by the molecule allows targets to be drugged that have historically been intractable to non-biological approaches. Bicycles represent a unique therapeutic class, combining the pharmacological properties normally associated with a biologic with the manufacturing and pharmacokinetic advantages of a small molecule, yet with no signs of immunogenicity observed to date.

Bicycles can be used as Bicycle conjugates to deliver toxin payloads and to precisely target local immune activation within tumors and as Bicycle T-cell modulators, which activate cytotoxic T-cells while circumventing the limitations of antibody and biologic therapies and better enabling combination therapy. Our lead product candidate, BT1718, is a Bicycle toxin conjugate currently being investigated in a Phase I/IIa open label dose escalation and expansion clinical trial sponsored by Cancer Research UK. BT1718 targets Membrane Type 1 Matrix Metalloproteinase (MT1-MMP), also known as MMP-14, which is highly expressed in many solid tumors.

Our strategic collaborations are based on the ability of Bicycles to address a wide variety of targets. Through collaborations with AstraZeneca, Oxurion, Innovate UK and the Dementia Discovery Fund, we work with companies that have deep therapeutic expertise outside of oncology to enable us to more efficiently develop novel medicines for patients.
Followers
7.7K
Website visits
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Mentions
52
Location: United Kingdom, England, Cambridge
Employees: 51-200
Total raised: $695.03M
Founded date: 2009

Investors 7

Funding Rounds 5

DateSeriesAmountInvestors
24.05.2024-$555M-
01.10.2020-$50M-
02.06.2017Series B$52M-
14.10.2014-$32M-
10.12.2012-$6.03M-

Mentions in press and media 52

DateTitleDescription
24.10.2024Innovate Cambridge launches strategy to accelerate innovation through increased startup investmentCambridge, UK has unveiled a plan to supercharge the impact of the Greater Cambridge area by doubling the rate at which it builds unicorns, doubling the venture capital investment the city’s startups receive, and creating twice as many scie...
25.05.2024ETF Partners Raises €285M for Sustainability VenturesETF Partners, Europe's original sustainability venture capital firm, has successfully raised €285 million in an oversubscribed round for its fourth fund. Founded in 2006, ETF Partners focuses on investing in fast-growing innovative companie...
24.05.2024Bicycle Therapeutics scores $555M investment for disease preventionCambridge medtech Bicycle Therapeutics has raised $555M in equity financing via a private placement. Bicycle Therapeutics draws on Sir Gregory Winter's Nobel-winning research to trial use of ‘bicycle’ molecules in cancer treatment by penetr...
24.05.2024€2.5B for NanoIC pilot line, ETF Partners raises €285M, and 10 Italian startups to watchThis week our research tracked more than 65 tech funding deals worth over €4.3 billion, and 15 exits, M&A transactions, rumours, and related news stories across Europe. In addition to this week's top financials, we've also indexed the m...
23.05.2024Bicycle Therapeutics Announces $555 Million Private Placement Equity Financing- Financing includes participation from new and existing investors - Strengthens balance sheet, with pro forma cash position of approximately $1.0 billion, extending expected financial runway into the second half of 2027 - Supports ongoing ...
19.09.2022Bicycle announces publication of article highlighting preclinical data from BT8009 program in molecular cancer therapeuticsBicycle Therapeutics announces publication of article highlighting preclinical data from BT8009 program in molecular cancer therapeutics Bicycle Therapeutics plc (NASDAQ:BCYC), a biotechnology company pioneering a new and differentiated cla...
12.07.2022Bicycle Therapeutics announces further expansion of Genentech Immuno-Oncology collaborationBicycle Therapeutics announces further expansion of Genentech Immuno-Oncology collaboration Genentech exercises second option to initiate an additional program under the 2020 collaboration agreement Bicycle Therapeutics plc (NASDAQ: BCYC), ...
04.11.2021Bicycle Therapeutics reports third quarter 2021 financial results and provides corporate updateBicycle Therapeutics reports third quarter 2021 financial results and provides corporate update Announced interim BT5528 Phase I clinical trial results and preliminary results from ongoing BT8009 Phase I clinical trial First Patient Dosed i...
13.10.2021Bicycle Therapeutics : Announces Pricing of Upsized Public Offering of $175 Million of American Depositary SharesBicycle Therapeutics plc (Nasdaq: BCYC), a biotechnology company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle®) technology, today announced the pricing of an underwritten publi...
12.10.2021Bicycle Therapeutics : Announces Proposed $125,000,000 Public Offering of American Depositary SharesBicycle Therapeutics plc (Nasdaq: BCYC), a biotechnology company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle®) technology, today announced that it has commenced an underwritte...
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